Dermal Fillers

How Long Does Botox Take to Kick in?

Botox takes two to three days to kick in. Botulinum toxin treatments stop signals from the nerve to the muscles by binding with SNARE. The binding is immediate, but it takes time for SNARE to shut down.

Botulinum toxin treatments enhance appearance by eliminating facial wrinkles and fine lines. Ageing, scars, congenital anomalies, and exposure to UV light can damage the skin, causing the formation of wrinkles. You cannot stop ageing, but you can lessen the signs of ageing. Your skin weakness is due to the loss of collagen;collagen is a protein found in connective tissues, skin, tendons, and cartilage, maintaining skin structure and elasticity. This article will explain botulinum toxin treatment and how long it takes to kick in.

How Long Do Botulinum Toxin Treatment Results Take to Kick in?

You can notice changes a few days after botulinum toxin injection depending on the area treated and the volume of botulinum toxin injected. You can see results faster in areas like the corners of the eye and forehead, but if the lines and wrinkles were deep, the results might take longer than expected. The results would be slow if larger muscles were injected with smaller volumes of the injection than when smaller muscles were injected with larger volumes.

What is Botox?

According to Satriyasa (2019),botulinum toxin injection reduces the appearance of facial wrinkles, frown lines, forehead creases, and crowfeet. The injection relaxes muscles and prevents their movement by blocking nerve signals.

Uses of Botox

  • Soften a square jawline
  • Correct a gummy smile
  • Diminish neck bands
  • Smooths crow’s feet, forehead furrows, frown lines, bunny lines, and lip lines

What is the Cost of Botox

The average cost of botulinum toxin injections varies depending on how advanced the signs are, the cosmetic doctor’s expertise and qualifications, and the time and effort used in the process. 

Procedure for Botulinum Toxin Injection

Before the injections, the cosmetic doctor numbs the treated area with a numbing cream or nerve block. The procedure is not painful, and most people do not feel much discomfort. However, if you are uncomfortable, the cosmetic doctor will numb the areas to be treated.

During the injection, the cosmetic doctor will inject your skin tissues or muscles with a botulinum toxin injection of your choice. The time will depend on the number of injections and the extent of wrinkles in the treatment area.

After the injection, do not touch, rub or massage the treated area for at least 24 hours to prevent the botulinum toxin from spreading to other sites. Botulinum toxin injection does not have downtime, and you can resume work right after the procedure.

Why Botox Takes Time

Botulinum toxin injection stops muscles from contracting. According toCarré et al. (2022), the botulinum toxin binds with SNARE, a protein that sends signals from the nerves to the muscle stopping the communication. Although the binding is quick, it takes time for the SNARE to shut down.

Side Effects and Complications of Botox

According toWitmanowski&Błochowiak (2020),botulinum toxin injections are safe when done by a qualified and experienced cosmetic doctor or aesthetic practitioner. The common side effects of the anti-wrinkle injections are bruising, flu-like symptoms, nausea, temporal facial weakness, headache, and redness. These side effects will subside after a few days. On rare occasions, you can experience complications like frozen facial expressions, botulism-like signs like difficulty breathing, slurred speech, and trouble swallowing due to the injection spreading beyond the area of treatment. Botox can cause an allergic reaction in individuals allergic to cow milk proteins. Also, Botox is not safe for pregnant and breastfeeding women.

How Long Does Botox Last?

You can schedule botulinum toxin retouch after two or three months when you notice the results resolve. For first-timers, the effect of the neurotoxin wears off faster than for those who have had second or third treatments. The duration of Botox is affected by the quality of Botox, metabolism, size and depth of wrinkles, how often you work out, the area treated, amount of Botox injected, the experience of the cosmetic doctor, and how often you have Botox treatments.

Frequently Asked Questions about Botox

What Areas Can Be Treated with Botulinum Toxin Injections?

The botulinum toxin injection eliminates wrinkles, crow’s feet, and frown lines. The anti-wrinkle treatment can also be injected into jaw muscles to alleviate pain from teeth grinding.

How Long Does Botox Last?

Botulinum toxin treatment results can last up to six months from the injection day. Due to metabolism, the muscle movements will slowly return to the treated areas. You can undergo retouching of Botox to maintain your look.

What Does a Botulinum Toxin Treatment Feel Like?

The anti-wrinkle treatment is not painful, even though you may initially feel discomfort. Anerve block or numbing cream can be used before the procedure.

How Does Botox Work?

Botulinum toxin treatment blocks signals from the nerve to the muscles; this stops musclemovements. The skin develops wrinkles and fine lines due to repetitive skin contractions.

How Soon Will I See the Botox Results?

You can see Botox results after two to three days, depending on the amount of Botox and the extent of the wrinkles.


You can expect results a few days after the anti-wrinkle injection; this will depend on the area treated, and the volume injected. The anti-wrinkle treatment binds with SNARE to cut off communication between the nerves and the muscles; this stops musclemovements in the area injected. Even though binding with SNARE takes a short time, the muscles require sometime to relax. Botulinum toxin injections help smooth wrinkles, frown lines, fine lines, and lip lines. The cost of a botulinum toxin injection varies, depending on the cosmetic doctor’s expertise, the number of injections, and the difficulty of the injection. Botox injections are safe with minor side effects like bruising and nausea.


Carré, D., Martin, V., Kouidri, Y., Morin, R., Norlund, M., Gomes, A., … &Lezmi, S. (2022). The distribution of neuromuscular junctions depends on muscle pennation, when botulinum neurotoxin receptors and SNAREs expression are uniform in the rat. Toxicon212, 34-41.

Deshmukh, S. N., Dive, A. M., Moharil, R., & Munde, P. (2016). Enigmatic insight into collagen. Journal of oral and maxillofacial pathology: JOMFP20(2), 276.

Satriyasa, B. K. (2019). Botulinum toxin (Botox) A for reducing the appearance of facial wrinkles: a literature review of clinical use and pharmacological aspect. Clinical, cosmetic and investigational dermatology12, 223.

Witmanowski, H., & Błochowiak, K. (2020). The whole truth about botulinum toxin – a review. Postepydermatologiiialergologii37(6), 853–861.

Monika Wasserman