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Dermal Fillers

What are Dermal Fillers Made of?

Dermal fillers have gained immense popularity in the world of cosmetic enhancements, offering a non-surgical solution to combat the signs of aging, enhance facial features, and rejuvenate the skin. While they are widely used and trusted, it’s essential to understand what dermal fillers are made of, their various types, and the safety considerations associated with these treatments. In this comprehensive guide, we delve into the ingredients, types, and safety aspects of dermal fillers to help you make informed decisions about enhancing your appearance.

Understanding Dermal Fillers

Dermal fillers, also known as soft tissue fillers or wrinkle fillers, are injectable substances used to add volume, reduce wrinkles, and restore a youthful look to the face. These treatments are minimally invasive and offer quick, noticeable results. Dermal fillers are a versatile option for addressing various cosmetic concerns, including:

Wrinkles and Fine Lines

Fillers can smooth out lines and wrinkles, particularly around the mouth, eyes, and forehead.

Volume Loss

They can restore lost volume in the cheeks, temples, and under the eyes.

Lip Enhancement

Fillers are commonly used to enhance lip volume and shape.


Dermal fillers can also improve the appearance of scars, including acne scars.

To understand how dermal fillers work, it’s essential to examine their composition and ingredients.

What Are Dermal Fillers Made Of?

The ingredients in dermal fillers can vary depending on the type and brand. However, most dermal fillers are primarily composed of one of the following substances:

Hyaluronic Acid (HA)

Hyaluronic acid is a naturally occurring substance in the skin that helps maintain hydration and volume. HA fillers are popular for their versatility and safety profile. Brands like Juvederm, Restylane, and Belotero use HA as their primary ingredient.

Calcium Hydroxylapatite (CaHA)

CaHA is a mineral-like compound found in bones. It’s used in fillers like Radiesse to stimulate collagen production and provide longer-lasting results.

Poly-L-lactic Acid

Poly-L-lactic acid is a biodegradable synthetic substance. It’s used in Sculptra to stimulate collagen growth and improve skin texture over time.

Polymethylmethacrylate (PMMA)

PMMA is a synthetic material that provides long-lasting volume. Bellafill is an example of a filler containing PMMA microspheres.

Autologous Fat (Fat Transfer)

Fat can be harvested from the patient’s own body (usually from areas like the abdomen or thighs) and then purified and injected as a filler. Fat transfer offers natural-looking results and can be a permanent solution in some cases.

Types of Dermal Fillers

Dermal fillers are categorized into different types based on their ingredients and purposes:

Temporary Fillers

HA fillers and some collagen-stimulating fillers fall into this category. Results typically last from 6 months to 2 years.

Semi-Permanent Fillers

Fillers like Sculptra provide longer-lasting results, often up to 2 years or more.

Permanent Fillers

PMMA-containing fillers and autologous fat transfer can offer results that may last indefinitely, although touch-up sessions may still be necessary.

Safety Considerations

While dermal fillers are generally considered safe when administered by qualified professionals, there are essential safety considerations to keep in mind:

Provider Qualifications

Ensure that your treatment is performed by a licensed and experienced medical professional.

Allergies and Sensitivities

Discuss any known allergies or sensitivities with your provider to choose the most suitable filler.

Product Authenticity

Only receive treatments using FDA-approved, authentic fillers from reputable sources.

Side Effects

Common side effects include temporary swelling, bruising, and redness. These usually subside within a few days.


While rare, complications like infection, lump formation, and vascular occlusion can occur. A skilled practitioner can minimize these risks.

Follow-up Care

Attend follow-up appointments as recommended by your provider to ensure optimal results and address any concerns.

Combining Dermal Fillers with Other Treatments

Combining Dermal Fillers with Botox

One common combination in the world of aesthetics is the use of dermal fillers alongside Botox (Botulinum Toxin Type A). Botox is primarily used to relax facial muscles, reducing the appearance of dynamic wrinkles (wrinkles caused by muscle movement). By strategically using Botox in areas like the forehead, crow’s feet, and frown lines in combination with dermal fillers, you can achieve a comprehensive rejuvenation effect.


The combination of Botox and dermal fillers can provide a more balanced, refreshed, and youthful appearance. Botox addresses dynamic wrinkles, while dermal fillers add volume and smooth static wrinkles.

Combining Dermal Fillers with Laser Therapy

Laser therapy, such as fractional laser resurfacing or intense pulsed light (IPL), is often used to improve skin texture, reduce pigmentation irregularities, and stimulate collagen production. When combined with dermal fillers, laser therapy can create a multi-dimensional approach to skin rejuvenation.


Dermal fillers can plump and enhance the skin’s appearance, while laser therapy can address skin tone, texture, and pigmentation issues. The combination can result in a more youthful and radiant complexion.

Combining Dermal Fillers with Chemical Peels

Chemical peels are another effective method for improving skin texture and reducing signs of aging. When used alongside dermal fillers, chemical peels can help exfoliate the skin’s surface and promote the absorption of fillers for enhanced results.


Combining chemical peels with dermal fillers can result in smoother, more even-toned skin. The peeling process can also stimulate collagen production, enhancing the longevity of filler results.

Combining Dermal Fillers with Microneedling

Microneedling, or collagen induction therapy, involves the use of tiny needles to create controlled micro-injuries in the skin. When combined with dermal fillers, microneedling can help enhance collagen production and improve the overall texture and quality of the skin.


The combination of microneedling and dermal fillers can provide a synergistic effect, promoting skin rejuvenation and long-lasting results.

Customized Treatment Plans

The key to successful combination treatments is customization. A skilled practitioner will assess your unique needs, goals, and skin condition before recommending a tailored treatment plan. Combining treatments should be done strategically, taking into account factors such as the type of dermal filler, the choice of complementary procedures, and the timing of each treatment.

Safety Considerations

While combining treatments can yield exceptional results, it’s essential to ensure that each procedure is performed by a qualified and experienced practitioner. Open communication with your provider is crucial to discuss your expectations, address any concerns, and plan your treatments accordingly.


Dermal fillers have revolutionized non-surgical cosmetic treatments, offering a range of options to address various aesthetic concerns. Understanding the ingredients, types, and safety considerations associated with dermal fillers is essential for making informed decisions about your appearance enhancement journey. Always consult with a qualified and experienced practitioner who can recommend the most suitable filler and treatment plan tailored to your unique needs and goals.

Ksenia Sobchak