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Dermal Fillers

What Are Fillers Made of?

Some customers usually ask what the fillers are made of. This article discusses more about the ingredients in fillers, how fillers can improve the look, and the risks and side effects of this treatment.

Dermal fillers are compounds injected under the skin to improve facial structure, regain lost volume, and reduce lines and creases. Several clients each year choose the standard facial aesthetic procedure that offers a cost-effective solution to look youthful without surgery or downtime. Dermal fillers are not suitable for everybody as long as they are over 18 and not pregnant or lactating. Patients with specific illnesses, including certain allergies or bleeding disorders, may not be fit for dermal fillers. However, if a cosmetic doctor says dermal fillers are possible for you, be aware that all pharmaceutical treatments have advantages and disadvantages.

What Are Fillers Made of?

Cosmetic doctors can choose from a selection of approved filler products. Fillers are often grouped according to the material they are constructed of. Ensure to obtain brand-name fillers that have been authorized and are only accessible through a qualified doctor, including a board-certified cosmetic doctor, although it’s mandatory.

Hyaluronic Acid

According to Bukhari et al. (2018), the skin contains hyaluronic acid, which is a substance that occurs naturally. It keeps skin moisturized and plump. Hyaluronic acid fillers have a soft, gel-like texture. McDonald &Knollinger (2019) stated that Hyaluronic acid the effects lastsfor at least six to twelve months. Brusini et al. (2022)suggested that many hyaluronic acid fillers have lidocaine incorporated to lessen pain during and after the procedure.

Calcium Hydroxylapatite

Calcium hydroxylapatite is present in human bones. According to Wu et al. (2022), the calcium elements are tiny and embedded in a silky gel when employed as a filler. A calcium hydroxylapatite filler often has a higher viscosity than a HA filler and lasts longer.Mahendran et al. (2020) stated that calcium hydroxylapatite, utilized for deeper wrinkles and lines, assists in creating natural collagen.

Poly-L -Lactic Acid

The synthetic material poly-L-lactic acid is compatible with or safe for usage inside the body. It is also biodegradable. It is a component of medical equipment like dissolvable stitches. The filler gel disappears a few days after treatment; therefore, technically, poly-L-lactic acid treatments are referred to as “collagen stimulators” because their primary method of reducing fine wrinkles is by assisting the skin’s natural collagen synthesis. Christen (2022) showed that deeper facial wrinkles are often treated with poly-L-lactic acid, and the effects can continue for more than two years.


Polymethylmethacrylate (PMMA), a synthetic, biocompatible material, is used in medicine. Christen &Vercesi (2020) discovered that Polymethylmethacrylate is used in dermal fillers in the manner of a microsphere which stays subcutaneously for an extended period to continue offering support. Collagen, a protein in the skin that gives it firmness and structure, will also be present in polymethylmethacrylate fillers.

Autologous Fat Injections

According to Krastev et al. (2020), the injectable filler procedure that needs surgery is autologous fat injections. Autologous, which implies “from the same individual,” fat is taken from another location, usually via liposuction. AllahyariFard (2018) showed that the autologous fat is cleaned and infused into the region to add volume to the lower eyelids, temples, cheeks, or other parts of the face. However, the effects may last for several years. Only a skilled, board-certified cosmetic doctor should administer fat injections to conduct them safely and produce excellent outcomes.

Choosing the Provider for Filler Treatments

When choosing a provider for cosmetic procedures, patients should offer their decision the same degree of thought and consideration as they would for surgical operations. A non-surgical filler procedure is a clinical technique that calls for specialized training, expertise, and skill to assure safe procedures and outcomes appear natural. Patients should select a cosmetic doctor with a thorough understanding of facial anatomy, a keen aesthetic sense, and skills.

Ensure a cosmetic doctor you choose has a track record in cosmetic medicine, extensive training, and expertise in injecting fillers. Seek out before-and-after pictures of a provider’s patients.

How Can Fillers Improven Appearance?

Dermal fillers, also called “wrinkle fillers,” reduce wrinkles. De Maio (2021) listed a few problems that dermal fillers can treat:

Eliminate wrinkles around the mouth and nose.

  • Improve and add volume to temples or depressed cheeks.
  • Vertical lip lines are lessened.
  • Boost and plump the lips.
  • Defining a chin wrinkle
  • better symmetry between facial features

Risks of Fillers

Dermal filler use carries hazards, like any other medical procedure. Vidič&Bartenjev (2018) stated the side effects and complicationsof dermal fillers; rash, itching, tenderness, pain, swelling, redness, and bruising. The study above also showed that most adverse reactions start after injection and disappear after a few weeks. Sometimes, adverse effects don’t appear until weeks, months, or even years later. Patients should be checked for allergies before obtaining dermal fillers created with certain materials, notably those originating from animals, including collage.

Unintentional injection into a coronary artery or vein is the dermal filler risk that poses the greatest danger. Sito et al. (2019) noted that a filler that gets into a blood artery might result in blindness, stroke, or skin necrosis. Despite the minimal likelihood that this may occur, the following problems may be severe and even permanent if it does.

FAQs about Fillers

What Liquid Is Used in Fillers?

The mineral-like substance calcium hydroxylapatite, which is present in bones, is one of the ingredients used in dermal fillers. HA is present in several bodily fluids and tissues and gives the skin a plump appearance. A transparent gel called polyalkylimide is safe for the body.

How Long Do Fillers Last?

Jung (2019) stated that deep filler treatment might last for a year, but more recent medicines on the market could last for two years.

What Are the Side Effects of Fillers?

Fillers are side effects that include wounds on the face when the injection reaches into a blood vessel deeply, lumps, skin rash with itching, infection, skin discomfort, and redness.

What Happens When I Stop Getting Fillers?

Many patients using dermal fillers believe that if they stop having injections,  their ]skin will start to wrinkle or sag. The treated region will revert to its previous appearance as the treatment fades off. Wrinkles won’t get worse if a patient stops the treatment.


Fillers are Hyaluronic Acid, Calcium Hydroxylapatite, poly-L-lactic acid a, Polymethylmethacrylate, and autologous fat injections. Asking about education and credentials will help confirm that a patient gets treatment from a board-certified cosmetic surgeon or skilled dermatologist. A patient can obtain natural, stunning, and secure results with proper planning and consultation with a cosmetic doctor.


Bukhari, S. N. A., Roswandi, N. L., Waqas, M., Habib, H., Hussain, F., Khan, S., … & Hussain, Z. (2018). Hyaluronic Acid, A Promising Skin Rejuvenating Biomedicine: A Review Of Recent Updates And Pre-Clinical And Clinical Investigations On Cosmetic And Nutricosmetic Effects. International Journal Of Biological Macromolecules, 120, 1682-1695.

Brusini, R., Iehl, J., Clerc, E., Gallet, M., Bourdon, F., &Faivre, J. (2022). Comparative Preclinical Study Of Lidocaine And Mepivacaine In Resilient Hyaluronic Acid Fillers. Pharmaceutics, 14(8), 1553.

Krastev, T. K., Schop, S. J., Hommes, J., Piatkowski, A., & Van Der Hulst, R. R. (2020). A Systematic Review And Meta-Analysis Is An Autologous Fat Transfer To Treat Fibrosis And Scar-Related Conditions. Journal Of Plastic, Reconstructive & Aesthetic Surgery, 73(11), 2033-2048.

Wu, J., Wang, S., Zheng, Z., & Li, J. (2022). Fabrication Of Biologically Inspired Electrospun Collagen/Silk Fibroin/Bioactive Glass Composited Nanofibrous Scaffold To Accelerate The Treatment Efficiency Of Bone Repair. Regenerative Therapy, 21, 122-138.

Jung, G. S. (2019). Filler Rhinoplasty Based On Anatomy: The Dual Plane Technique. JPRAS Open, 20, 94-100.

Sito, G., Manzoni, V., &Sommariva, R. (2019). Vascular Complications After Facial Filler Injection: A Literature Review And Meta-Analysis. The Journal Of Clinical And Aesthetic Dermatology, 12(6), E65.

Vidič, M., &Bartenjev, I. (2018). An Adverse Reaction After Hyaluronic Acid Filler Application: A Case Report. Acta Dermatovenerol Alp PannonicaAdriat, 27(3), 165-167.

De Maio, M. (2021). MD Codes™: A Methodological Approach To Facial Aesthetic Treatment With Injectable Hyaluronic Acid Fillers. Aesthetic Plastic Surgery, 45(2), 690-709.

AllahyariFard, S. (2018). Surgical And Non-Surgical Methods In Facial Rejuvenation.

Mahendran, K. V., Somasundaram, J., &Sivaswamy, V. (2020). Role Of Dermal Fillers In Aesthetic Dentistry. Indian Journal Of Forensic Medicine & Toxicology, 14(4).

Christen, M. O. (2022). Collagen Stimulators In Body Applications: A Review Focused On Poly-L-Lactic Acid (PLLA). Clinical, Cosmetic And Investigational Dermatology, 15, 997.

Mcdonald, J. E., &Knollinger, A. M. (2019). The Use Of Hyaluronic Acid Subdermal Filler For Entropion In Canines And Felines: 40 Cases. Veterinary Ophthalmology, 22(2), 105-115.

Marie Salbuvik